Tungiasis Treatment & Management: Approach Considerations, Topical Treatments, Deterrence and Prevention (2024)

  1. Veraldi S, Valsecchi M. Imported tungiasis: a report of 19 cases and review of the literature. Int J Dermatol. 2007 Oct. 46(10):1061-6. [QxMD MEDLINE Link].

  2. Gibbs SS. The diagnosis and treatment of tungiasis. Br J Dermatol. 2008 Sep. 159(4):981. [QxMD MEDLINE Link].

  3. Feldmeier H, Eisele M, Van Marck E, Mehlhorn H, Ribeiro R, Heukelbach J. Investigations on the biology, epidemiology, pathology and control of Tunga penetrans in Brazil: IV. Clinical and histopathology. Parasitol Res. 2004 Oct. 94(4):275-282. [QxMD MEDLINE Link].

  4. Pilger D, Schwalfenberg S, Heukelbach J, Witt L, Mehlhorn H, Mencke N, et al. Investigations on the biology, epidemiology, pathology, and control of Tunga penetrans in Brazil: VII. The importance of animal reservoirs for human infestation. Parasitol Res. 2008 Apr. 102(5):875-80. [QxMD MEDLINE Link].

  5. Caumes E, Carrière J, Guermonprez G, Bricaire F, Danis M, Gentilini M. Dermatoses associated with travel to tropical countries: a prospective study of the diagnosis and management of 269 patients presenting to a tropical disease unit. Clin Infect Dis. 1995 Mar. 20(3):542-8. [QxMD MEDLINE Link].

  6. Clyti E, Couppie P, Deligny C, Jouary T, Sainte-Marie D, Pradinaud R. [Effectiveness of 20% salicylated vaseline in the treatment of profuse tungiasis. Report of 8 cases in French Guiana]. Bull Soc Pathol Exot. 2003 Jan. 96(5):412-4. [QxMD MEDLINE Link].

  7. Hotez PJ, Bottazzi ME, Franco-Paredes C, Ault SK, Periago MR. The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination. PLoS Negl Trop Dis. 2008 Sep 24. 2(9):e300. [QxMD MEDLINE Link]. [Full Text].

  8. Thielecke M, Raharimanga V, Rogier C, Stauss-Grabo M, Richard V, Feldmeier H. Prevention of tungiasis and tungiasis-associated morbidity using the plant-based repellent Zanzarin: a randomized, controlled field study in rural Madagascar. PLoS Negl Trop Dis. 2013. 7 (9):e2426. [QxMD MEDLINE Link].

  9. Coates SJ, Thomas C, Chosidow O, Engelman D, Chang AY. Ectoparasites: Pediculosis and tungiasis. J Am Acad Dermatol. 2020 Mar. 82 (3):551-569. [QxMD MEDLINE Link].

  10. Saboyá-Díaz MI, Nicholls RS, Castellanos LG, Feldmeier H. Current status of the knowledge on the epidemiology of tungiasis in the Americas. Rev Panam Salud Publica. 2022. 46:e124. [QxMD MEDLINE Link].

  11. Chadee DD. Tungiasis among five communities in south-western Trinidad, West Indies. Ann Trop Med Parasitol. 1998 Jan. 92(1):107-13. [QxMD MEDLINE Link].

  12. Muehlen M, Heukelbach J, Wilcke T, Winter B, Mehlhorn H, Feldmeier H. Investigations on the biology, epidemiology, pathology and control of Tunga penetrans in Brazil. II. Prevalence, parasite load and topographic distribution of lesions in the population of a traditional fishing village. Parasitol Res. 2003 Aug. 90(6):449-55. [QxMD MEDLINE Link].

  13. Girma M, Astatkie A, Asnake S. Prevalence and risk factors of tungiasis among children of Wensho district, southern Ethiopia. BMC Infect Dis. 2018 Sep 10. 18 (1):456. [QxMD MEDLINE Link].

  14. Fein H, Naseem S, Witte DP, Garcia VF, Lucky A, Staat MA. Tungiasis in North America: a report of 2 cases in internationally adopted children. J Pediatr. 2001 Nov. 139(5):744-6. [QxMD MEDLINE Link].

  15. Escamilla-Martinez E, Gómez-Martín B, Sánchez-Rodríguez R, Martínez-Nova A, Martínez-Granada LJ, Altube-Arabiurrutia E. Tungiasis--traveler's ectoparasitosis of the foot: a case report. Foot Ankle Int. 2008 Mar. 29(3):354-7. [QxMD MEDLINE Link].

  16. Bourée P, Ossé L, Rabenandrasana F. [Tungiasis, an uncommon ectoparisitic disease]. Rev Prat. 2009 Feb 20. 59(2):163-5. [QxMD MEDLINE Link].

  17. Eisele M, Heukelbach J, Van Marck E, Mehlhorn H, Meckes O, Franck S, et al. Investigations on the biology, epidemiology, pathology and control of Tunga penetrans in Brazil: I. Natural history of tungiasis in man. Parasitol Res. 2003 Jun. 90 (2):87-99. [QxMD MEDLINE Link].

  18. Feldmeier H, Sentongo E, Krantz I. Tungiasis (sand flea disease): a parasitic disease with particular challenges for public health. Eur J Clin Microbiol Infect Dis. 2013 Jan. 32(1):19-26. [QxMD MEDLINE Link].

  19. Obebe OO, Aluko OO. Epidemiology of tungiasis in sub-saharan Africa: a systematic review and meta-analysis. Pathog Glob Health. 2020 Oct. 114 (7):360-369. [QxMD MEDLINE Link].

  20. Sanusi ID, Brown EB, Shepard TG, Grafton WD. Tungiasis: report of one case and review of the 14 reported cases in the United States. J Am Acad Dermatol. 1989 May. 20(5 Pt 2):941-4. [QxMD MEDLINE Link].

  21. Mashek H, Licznerski B, Pincus S. Tungiasis in New York. Int J Dermatol. 1997 Apr. 36(4):276-8. [QxMD MEDLINE Link].

  22. Poppiti R Jr, Kambour M, Robinson MJ, Rywlin AM. Tunga penetrans in south Florida. South Med J. 1983 Dec. 76(12):1558-60. [QxMD MEDLINE Link].

  23. Brothers W, Heckmann R. Tungiasis (Tunga penetrans) in Utah. J Parasitol. 1979 Oct. 65(5):782. [QxMD MEDLINE Link].

  24. Hager J, Jacobs A, Orengo IF, Rosen T. Tungiasis in the United States: a travel souvenir. Dermatol Online J. 2008 Dec 15. 14(12):3. [QxMD MEDLINE Link].

  25. GIDEON Infectious Diseases - Tungiasis. Date Accessed: 5/5/2011. [Full Text].

  26. Nte AR, Eke FU. Jigger infestation in children in a rural area of Rivers State of Nigeria. West Afr J Med. 1995 Jan-Mar. 14(1):56-8. [QxMD MEDLINE Link].

  27. Arene FO. The prevalence of sand flea (Tunga penetrans) among primary and post-primary school pupils in Choba area of the Niger Delta. Public Health. 1984 Sep. 98(5):282-3. [QxMD MEDLINE Link].

  28. Ade-Serrano MA, Ejezie GC. Prevalence of tungiasis in Oto-Ijanikin village, Badagry, Lagos State, Nigeria. Ann Trop Med Parasitol. 1981 Aug. 75(4):471-2. [QxMD MEDLINE Link].

  29. de Carvalho RW, de Almeida AB, Barbosa-Silva SC, Amorim M, Ribeiro PC, Serra-Freire NM. The patterns of tungiasis in Araruama township, state of Rio de Janeiro, Brazil. Mem Inst Oswaldo Cruz. 2003 Jan. 98(1):31-6. [QxMD MEDLINE Link].

  30. Ugbomoiko US, Ofoezie IE, Heukelbach J. Tungiasis: high prevalence, parasite load, and morbidity in a rural community in Lagos State, Nigeria. Int J Dermatol. 2007 May. 46(5):475-81. [QxMD MEDLINE Link].

  31. Feldmeier H, Witt L, Schwalfenberg S, Linardi PM, Ribeiro RA, Capaz RA, et al. Investigations on the biology, epidemiology, pathology and control of Tunga penetrans in Brazil. VI. Natural history of the infestation in laboratory-raised Wistar rats. Parasitol Res. 2007 Dec. 102(1):1-13. [QxMD MEDLINE Link].

  32. Heukelbach J, Franck S, Feldmeier H. High attack rate of Tunga penetrans (Linnaeus 1758) infestation in an impoverished Brazilian community. Trans R Soc Trop Med Hyg. 2004 Jul. 98(7):431-4. [QxMD MEDLINE Link].

  33. Kehr JD, Heukelbach J, Mehlhorn H, Feldmeier H. Morbidity assessment in sand flea disease (tungiasis). Parasitol Res. 2007 Jan. 100(2):413-21. [QxMD MEDLINE Link].

  34. Kibaki L. Intensity the war on jiggers. Available at http://www.capitalfm.co.ke/eblog/2011/03/17. Accessed: June 20, 2013.

  35. Olukya G. Jiggers-something rotten in Uganda. Available at http:www.timeslive.co.za/africa/article722622.ece. Accessed: June 20, 2013.

  36. Deka MA. Mapping the Geographic Distribution of Tungiasis in Sub-Saharan Africa. Trop Med Infect Dis. 2020 Jul 24. 5 (3):[QxMD MEDLINE Link].

  37. Mazigo HD, Bahemana E, Konje ET, Dyegura O, Mnyone LL, Kweka EJ, et al. Jigger flea infestation (tungiasis) in rural western Tanzania: high prevalence and severe morbidity. Trans R Soc Trop Med Hyg. 2012 Apr. 106(4):259-63. [QxMD MEDLINE Link].

  38. Grupper M, Potasman I. Outbreak of tungiasis following a trip to Ethiopia. Travel Med Infect Dis. 2012 Sep. 10(5-6):220-3. [QxMD MEDLINE Link].

  39. Ugbomoiko US, Ofoezie IE, Heukelbach J. Tungiasis: high prevalence, parasite load, and morbidity in a rural community in Lagos State, Nigeria. Int J Dermatol. 2007 May. 46(5):475-81. [QxMD MEDLINE Link].

  40. Damazio OR, Silva MV. Tungiasis in schoolchildren in Criciúma, Santa Catarina State, South Brazil. Rev Inst Med Trop Sao Paulo. 2009 Mar-Apr. 51(2):103-8. [QxMD MEDLINE Link].

  41. Joseph JK, Bazile J, Mutter J, Shin S, Ruddle A, Ivers L, et al. Tungiasis in rural Haiti: a community-based response. Trans R Soc Trop Med Hyg. 2006 Oct. 100(10):970-4. [QxMD MEDLINE Link].

  42. Widmer CE, Azevedo FC. Tungiasis in a free-ranging jaguar (Panthera onca) population in Brazil. Parasitol Res. 2012 Mar. 110(3):1311-4. [QxMD MEDLINE Link].

  43. Linardi PM, Calheiros CM, Campelo-Junior EB, Duarte EM, Heukelbach J, Feldmeier H. Occurrence of the off-host life stages of Tunga penetrans (Siphonaptera) in various environments in Brazil. Ann Trop Med Parasitol. 2010 Jun. 104(4):337-45. [QxMD MEDLINE Link].

  44. Muehlen M, Feldmeier H, Wilcke T, Winter B, Heukelbach J. Identifying risk factors for tungiasis and heavy infestation in a resource-poor community in northeast Brazil. Trans R Soc Trop Med Hyg. 2006 Apr. 100(4):371-80. [QxMD MEDLINE Link].

  45. Ugbomoiko US, Ariza L, Ofoezie IE, Heukelbach J. Risk factors for tungiasis in Nigeria: identification of targets for effective intervention. PLoS Negl Trop Dis. 2007 Dec 5. 1(3):e87. [QxMD MEDLINE Link]. [Full Text].

  46. Lynne Elson 1,*, Katherine Wright 2, Jennifer Swift 2 and Herman Feldmeier 3. Control of Tungiasis in Absence of a Roadmap: Grassroots and Global Approaches. Tropical Medicine and Infectious Disease. 2017. 2:[Full Text].

  47. Feldmeier H, Heukelbach J, Eisele M, Sousa AQ, Barbosa LM, Carvalho CB. Bacterial superinfection in human tungiasis. Trop Med Int Health. 2002 Jul. 7(7):559-64. [QxMD MEDLINE Link].

  48. Joseph JK, Bazile J, Mutter J, Shin S, Ruddle A, Ivers L. Tungiasis in rural Haiti: a community-based response. Trans R Soc Trop Med Hyg. 2006 Oct. 100(10):970-4. [QxMD MEDLINE Link].

  49. Rathe M, Rafn A, Poulsen T, Mohey R. [Tungiasis case after a trip to Kenya]. Ugeskr Laeger. 2009 Mar 2. 171(10):818. [QxMD MEDLINE Link].

  50. Heukelbach J, Wilcke T, Eisele M, Feldmeier H. Ectopic localization of tungiasis. Am J Trop Med Hyg. 2002 Aug. 67(2):214-6. [QxMD MEDLINE Link].

  51. Veraldi S, Schianchi R, Cremonesi R. Bullous tungiasis. Int J Dermatol. 2005 Dec. 44(12):1067-9. [QxMD MEDLINE Link].

  52. Di Stefani A, Rudolph CM, Hofmann-Wellenhof R, Müllegger RR. An additional dermoscopic feature of tungiasis. Arch Dermatol. 2005 Aug. 141(8):1045-6. [QxMD MEDLINE Link].

  53. Cabrera R, Daza F. Dermoscopy in the diagnosis of tungiasis. Br J Dermatol. 2009 May. 160(5):1136-7. [QxMD MEDLINE Link].

  54. Bauer J, Forschner A, Garbe C, Röcken M. Dermoscopy of tungiasis. Arch Dermatol. 2004 Jun. 140(6):761-3. [QxMD MEDLINE Link].

  55. Smith MD, Procop GW. Typical histologic features of Tunga penetrans in skin biopsies. Arch Pathol Lab Med. 2002 Jun. 126(6):714-6. [QxMD MEDLINE Link].

  56. Eisele M, Heukelbach J, Van Marck E, Mehlhorn H, Meckes O, Franck S, et al. Investigations on the biology, epidemiology, pathology and control of Tunga penetrans in Brazil: I. Natural history of tungiasis in man. Parasitol Res. 2003 Jun. 90(2):87-99. [QxMD MEDLINE Link].

  57. Thielecke M, Raharimanga V, Rogier C, Stauss-Grabo M, Richard V, Feldmeier H. Prevention of tungiasis and tungiasis-associated morbidity using the plant-based repellent Zanzarin: a randomized, controlled field study in rural Madagascar. PLoS Negl Trop Dis. 2013. 7 (9):e2426. [QxMD MEDLINE Link].

  58. Heukelbach J. Revision on tungiasis: treatment options and prevention. Expert Rev Anti Infect Ther. 2006 Feb. 4 (1):151-7. [QxMD MEDLINE Link].

  59. Thielecke M, Nordin P, Ngomi N, Feldmeier H. Treatment of Tungiasis with dimeticone: a proof-of-principle study in rural Kenya. PLoS Negl Trop Dis. 2014. 8 (7):e3058. [QxMD MEDLINE Link].

  60. Miller H, Trujillo-Trujillo J, Mutebi F, Feldmeier H. Efficacy and safety of dimeticones in the treatment of epidermal parasitic skin diseases with special emphasis on tungiasis: an evidence-based critical review. Braz J Infect Dis. 2020 Mar-Apr. 24 (2):170-177. [QxMD MEDLINE Link].

  61. Abrha S, Heukelbach J, Peterson GM, Christenson JK, Carroll S, Kosari S, et al. Clinical interventions for tungiasis (sand flea disease): a systematic review. Lancet Infect Dis. 2021 Aug. 21 (8):e234-e245. [QxMD MEDLINE Link].

  62. Tardin Martins AC, de Brito AR, Kurizky PS, Gonçalves RG, Santana YRT, de Carvalho FCA, et al. The efficacy of topical, oral and surgical interventions for the treatment of tungiasis: A systematic review of the literature. PLoS Negl Trop Dis. 2021 Aug. 15 (8):e0009722. [QxMD MEDLINE Link].

  63. Feldmeier H, Kehr JD, Heukelbach J. A plant-based repellent protects against Tunga penetrans infestation and sand flea disease. Acta Trop. 2006 Oct. 99(2-3):126-36. [QxMD MEDLINE Link].

  64. Heukelbach J, Eisele M, Jackson A, Feldmeier H. Topical treatment of tungiasis: a randomized, controlled trial. Ann Trop Med Parasitol. 2003 Oct. 97(7):743-9. [QxMD MEDLINE Link].

  65. Heukelbach J, Franck S, Feldmeier H. Therapy of tungiasis: a double-blinded randomized controlled trial with oral ivermectin. Mem Inst Oswaldo Cruz. 2004 Dec. 99(8):873-6. [QxMD MEDLINE Link].

  66. Feldmeier H, Heukelbach J, Ugbomoiko US, Sentongo E, Mbabazi P, von Samson-Himmelstjerna G, et al. Tungiasis--a neglected disease with many challenges for global public health. PLoS Negl Trop Dis. 2014 Oct. 8 (10):e3133. [QxMD MEDLINE Link].

  67. Buckendahl J, Heukelbach J, Ariza L, Kehr JD, Seidenschwang M, Feldmeier H. Control of tungiasis through intermittent application of a plant-based repellent: an intervention study in a resource-poor community in Brazil. PLoS Negl Trop Dis. 2010 Nov 9. 4(11):e879. [QxMD MEDLINE Link]. [Full Text].

  68. Mutebi F, von Samson-Himmelstjerna G, Feldmeier H, Waiswa C, Bukeka Muhindo J, Krücken J. Successful Treatment of Severe Tungiasis in Pigs Using a Topical Aerosol Containing Chlorfenvinphos, Dichlorphos and Gentian Violet. PLoS Negl Trop Dis. 2016 Oct. 10 (10):e0005056. [QxMD MEDLINE Link].

  69. Elson L, Randu K, Feldmeier H, Fillinger U. Efficacy of a mixture of neem seed oil (Azadirachta indica) and coconut oil (Cocos nucifera) for topical treatment of tungiasis. A randomized controlled, proof-of-principle study. PLoS Negl Trop Dis. 2019 Nov. 13 (11):e0007822. [QxMD MEDLINE Link].

Tungiasis Treatment & Management: Approach Considerations, Topical Treatments, Deterrence and Prevention (2024)
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