Insulin/IRDN Recombinant Monoclonal Antibody (rIRDN, 805) (3630-MSM9-P1ABX) (2024)

  • Primary Antibodies
  • Insulin Antibodies

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Insulin/IRDN Recombinant Monoclonal Antibody (rIRDN, 805) (3630-MSM9-P1ABX) (1)

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Insulin/IRDN Antibody (3630-MSM9-P1ABX) in IHC (P)

Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human pancreas using Insulin, IRDN Recombinant Monoclonal Antibody (Product # 3630-MSM9-P1ABX). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more

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Insulin/IRDN Recombinant Monoclonal Antibody (rIRDN, 805) (3630-MSM9-P1ABX) (2)

Insulin/IRDN Recombinant Monoclonal Antibody (rIRDN, 805) (3630-MSM9-P1ABX) (3)

Product Details

3630-MSM9-P1ABX

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL

-

SDS-PAGE(SDS-PAGE)

Assay-dependent

-

Product Specifications

Species Reactivity

Bovine,Human,Mouse,Pig,Rabbit

Host/Isotype

Mouse/ IgG1, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

rIRDN, 805

Immunogen

Recombinant full-length human Insulin protein

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Wet ice

Product Specific Information

Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

Target Information

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases:Ins; Insulin; Insulin-1; Insulin-2; preproinsulin; proinsulin

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Gene Aliases:AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins-1; Ins-2; Ins1; Ins2; Ins2-rs1; InsII; IRDN; Mody; MODY10; Mody4; proinsulin

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Molecular Function: Insulin/IRDN Recombinant Monoclonal Antibody (rIRDN, 805) (3630-MSM9-P1ABX) (4)growth factor

Function(s)

negative regulation of acute inflammatory responseglucose metabolic processregulation of cellular amino acid metabolic processacute-phase responseG-protein coupled receptor signaling pathwaypositive regulation of cell proliferationinsulin receptor signaling pathwaylipid biosynthetic processglycoprotein biosynthetic processpositive regulation of nitric oxide mediated signal transductionpositive regulation of glucose metabolic processpositive regulation of phosphatidylinositol 3-kinase signalinglactate biosynthetic processregulation of transmembrane transporter activitypositive regulation of cell migrationpositive regulation of protein autophosphorylationactivation of protein kinase B activitynegative regulation of NAD(P)H oxidase activitywound healinglipoprotein biosynthetic processnegative regulation of protein catabolic processglucose homeostasispositive regulation of MAPK cascadenegative regulation of gluconeogenesispositive regulation of fatty acid biosynthetic processpositive regulation of glycogen biosynthetic processpositive regulation of DNA replicationnegative regulation of glycogen catabolic processpositive regulation of glycolytic processpositive regulation of mitotic nuclear divisionnegative regulation of proteolysisnegative regulation of fatty acid metabolic processpositive regulation of glucose importpositive regulation of insulin receptor signaling pathwayalpha-beta T cell activationnegative regulation of protein secretionpositive regulation of cytokine secretionpositive regulation of peptidyl-tyrosine phosphorylationnegative regulation of lipid catabolic processpositive regulation of lipoprotein lipase activitypositive regulation of NF-kappaB transcription factor activitypositive regulation of protein kinase B signalingfatty acid homeostasisnegative regulation of respiratory burst involved in inflammatory responsepositive regulation of respiratory burstpositive regulation of protein localization to nucleuspositive regulation of dendritic spine maintenanceregulation of protein localization to plasma membranenegative regulation of reactive oxygen species biosynthetic processresponse to L-arginineneuron projection maintenancenegative regulation of feeding behaviorsignal transductionfeeding behaviorprotein secretionresponse to heatresponse to glucosepositive regulation of gene expressionresponse to nutrient levelspositive regulation of insulin secretionresponse to foodnegative regulation of appetitepositive regulation of mammary gland epithelial cell proliferationpositive regulation of Rho protein signal transductionestradiol secretionnegative regulation of apoptotic processglucose import in response to insulin stimuluspositive regulation of protein secretionresponse to growth hormonepositive regulation of peptide hormone secretionpositive regulation of cell maturationnegative regulation of lactationpositive regulation of lactationpositive regulation of blood circulationresponse to butyrateMAPK cascaderegulation of transcription, DNA-templatedER to Golgi vesicle-mediated transportcell-cell signalingglucose transportpositive regulation of cell growthpositive regulation of cellular protein metabolic processnegative regulation of protein oligomerizationregulation of protein localizationcellular protein metabolic processpositive regulation of nitric oxide biosynthetic processpositive regulation of cell differentiationnegative regulation of vasodilationpositive regulation of vasodilationpositive regulation of lipid biosynthetic processregulation of protein secretionpositive regulation of nitric-oxide synthase activitypositive regulation of brown fat cell differentiationnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathwaycarbohydrate metabolic processnegative regulation of transcription from RNA polymerase II promoteractivation of MAPK activityER overload responseactivation of JUN kinase activitymyoblast fusionregulation of gene expressionmyotube differentiationlipid catabolic processregulation of phosphorylationregulation of protein bindingpositive regulation of phosphatidylinositol 3-kinase activitycanonical Wnt signaling pathwayintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Process(es)

protease bindinginsulin receptor bindinginsulin-like growth factor receptor bindinghormone activityidentical protein bindingprotein bindingchaperone bindingprotein complex binding

It has to be done as per old AB suggested Products section.

Insulin/IRDN Recombinant Monoclonal Antibody (rIRDN, 805) (3630-MSM9-P1ABX) (2024)
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