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Cite Angiotensin I Converting Enzyme (ACE)/CD143 Monoclonal Antibody (ACE/3764)
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Angiotensin I Converting Enzyme (ACE)/CD143 Antibody (1636-MSM4-P1) in IHC (P)
IHC analysis of formalin-fixed, paraffin-embedded human colon carcinoma. Staining using ACE/3764 at 2 µg/mL in PBS for 30 min RT. HIER: Tris/EDTA, pH9.0, 45 min. 2nd Ab: HRP-polymer, 30 min. DAB, 5 min. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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Product Details
1636-MSM4-P1
Applications
Tested Dilution
Publications
Immunohistochemistry (Paraffin) (IHC (P))
1-2 µg/mL
-
ELISA(ELISA)
Assay-dependent
-
Peptide Array(Array)
Assay-dependent
-
Immunoelectrophoresis(IE)
Assay-dependent
-
SDS-PAGE(SDS-PAGE)
Assay-dependent
-
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
ACE/3764
Immunogen
Full-length recombinant human ACE/CD143 protein
Conjugate
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
Antibody is stable for 24 months.
Positive Control: Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Cellular Localization: Cell Surface
Specificity Comments: This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.
Target Information
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases:ACE; angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript; Angiotensin-converting enzyme; carboxycathepsin; CD143; CD143 antigen; dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase I; Kininase II; MGC26566; peptidase P; testicular ECA
UniProt ID:(Human) P12821
Entrez Gene ID:(Human) 1636
Molecular Function: 
metalloprotease protease protein modifying enzyme
Function(s)
kidney developmentblood vessel remodelingangiotensin maturationangiotensin catabolic process in bloodregulation of renal output by angiotensinneutrophil mediated immunityantigen processing and presentation of peptide antigen via MHC class Iregulation of systemic arterial blood pressure by renin-angiotensinspermatogenesisregulation of blood pressureregulation of smooth muscle cell migrationregulation of vasoconstrictionmononuclear cell proliferationregulation of vasodilationhormone catabolic processpeptide catabolic processbeta-amyloid metabolic processarachidonic acid secretionheart contractionregulation of angiotensin metabolic processhematopoietic stem cell differentiationpositive regulation of protein tyrosine kinase activitycell proliferation in bone marrowpositive regulation of peptidyl-tyrosine autophosphorylationregulation of hematopoietic stem cell proliferationnegative regulation of gap junction assemblypositive regulation of peptidyl-cysteine S-nitrosylation
Process(es)
endopeptidase activitycarboxypeptidase activitydrug bindingmetallopeptidase activityexopeptidase activitytripeptidyl-peptidase activitypeptidyl-dipeptidase activityzinc ion bindingchloride ion bindingmitogen-activated protein kinase kinase bindingbradykinin receptor bindingmitogen-activated protein kinase bindingmetallodipeptidase activity
It has to be done as per old AB suggested Products section.
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